Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.61 |
| ▸ | CDK8 | P49336 | 2/20 | 0.61 |
| ▸ | GSK3B | P49841 | 7/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.58 |
| ▸ | CLK2 | P49760 | 2/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.58 |
| ▸ | CLK3 | P49761 | 1/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.58 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207604 | 0.83 | PIK3CA (0.63) | AXLGSK3BCDK5CLK4DYRK3 | |
| SCHEMBL23098906 | 0.81 | PIK3CA (0.49) | AXLCDK8GSK3BCDK5CLK4 | |
| SCHEMBL29930749 | 0.81 | KIT (0.55) | DYRK1APIK3CAPIK3C3MAP4K4NTRK1 | |
| SCHEMBL24155852 | 0.81 | MEN1 (0.51) | AXLCDK8GSK3BCDK5CLK4 | |
| SCHEMBL14338803 | 0.81 | CDK5 (0.47) | AXLCDK8GSK3BCDK5CLK4 | |
| SCHEMBL29930392 | 0.80 | PIK3C3 (0.52) | AXLGSK3BCDK5CLK4DYRK3 | |
| SCHEMBL24137515 | 0.80 | RPS6KB1 (0.52) | AXLGSK3BCLK4CLK2DYRK1A | |
| SCHEMBL11134013 | 0.79 | TGFBR1 (0.47) | AXLPIK3CAPIK3CDPIK3R1PIK3CB | |
| SCHEMBL15639535 | 0.79 | GSK3B (0.44) | AXLCDK8GSK3BCDK5CLK4 | |
| SCHEMBL1585618 | 0.78 | CDK8 (0.50) | AXLCDK8GSK3BCDK5CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |
| US-11446398-B2 | Regulated biocircuit systems | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-09-20 | — | — | US | disclosed |