Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.67 |
| ▸ | TTK | P33981 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.49 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930537 | 0.86 | DYRK1A (0.69) | DYRK1BDYRK1ATTKMAPK8PDE5A | |
| SCHEMBL29930317 | 0.82 | DYRK1B (0.68) | DYRK1BDYRK1ATTKMAPK8CLK1 | |
| SCHEMBL29930540 | 0.80 | DYRK1B (0.62) | DYRK1BDYRK1AMAPK8CDK5ALDH1A1 | |
| SCHEMBL29930667 | 0.80 | DYRK1B (0.70) | DYRK1BDYRK1ATTKMAPK8CLK1 | |
| SCHEMBL29930770 | 0.79 | DYRK1B (0.58) | DYRK1BDYRK1AMAPK8IDO1CLK1 | |
| SCHEMBL38651912 | 0.79 | NCOA1 (0.53) | DYRK1BDYRK1AHTTSMN1; SMN2MEN1 | |
| SCHEMBL5061384 | 0.76 | DYRK1A (0.57) | DYRK1BDYRK1ATTKMAPK8PDE1A | |
| SCHEMBL38652158 | 0.76 | AURKA (0.48) | DYRK1BDYRK1AMAPK8CDK5HTT | |
| SCHEMBL28562998 | 0.76 | DYRK1B (0.61) | DYRK1BDYRK1APDE1APDE1BPDE3B | |
| SCHEMBL4344646 | 0.75 | PDE5A (0.50) | DYRK1BDYRK1ATTKMAPK8PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |