Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 8/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.44 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.44 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.40 |
| ▸ | CLK2 | P49760 | 3/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5061384 | 0.84 | DYRK1A (0.57) | DYRK1BDYRK1AFGFR1MAP2K4CDK2 | |
| SCHEMBL29930484 | 0.84 | DYRK1B (0.56) | DYRK1BDYRK1APDPK1HSP90AB1FGFR1 | |
| SCHEMBL28559332 | 0.83 | DYRK1A (0.44) | DYRK1BDYRK1AFGFR1MAPK1CDK2 | |
| SCHEMBL29930540 | 0.82 | DYRK1B (0.62) | DYRK1BDYRK1AFGFR1MAPK1MAP2K4 | |
| SCHEMBL28562998 | 0.81 | DYRK1B (0.61) | DYRK1BDYRK1AMAPK1SYKGSK3A | |
| SCHEMBL38652158 | 0.81 | AURKA (0.48) | DYRK1BDYRK1AFGFR1MAPK1CDK2 | |
| SCHEMBL29930747 | 0.79 | DYRK1B (0.67) | DYRK1BDYRK1AJAK2CDK5MAPK8 | |
| SCHEMBL29930698 | 0.79 | DYRK1A (0.60) | DYRK1BDYRK1APDPK1HSP90AB1FGFR1 | |
| SCHEMBL29930603 | 0.79 | MAPT (0.46) | DYRK1BDYRK1AIDO1TDO2 | |
| SCHEMBL38651912 | 0.78 | NCOA1 (0.53) | DYRK1BDYRK1AMAPK1CLK4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | claimed |
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |