Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 4/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930883 | 0.92 | AXL (0.42) | DYRK1AAURKARETSRCAXL | |
| SCHEMBL29930958 | 0.87 | AXL (0.39) | KITAURKARETSRCAXL | |
| SCHEMBL29930779 | 0.84 | AXL (0.41) | DYRK1ADYRK1BAURKARETSRC | |
| SCHEMBL29930517 | 0.83 | PTPN11 (0.47) | AURKARETSRCAXLKDR | |
| SCHEMBL29930820 | 0.81 | GSK3B (0.41) | AXLMERTKMAPTMEN1KMT2A | |
| SCHEMBL29930860 | 0.79 | DYRK1A (0.46) | DYRK1ADYRK1BAURKARETSRC | |
| SCHEMBL29930712 | 0.77 | DYRK1A (0.38) | DYRK1ADYRK1BAXLMERTKMAPT | |
| SCHEMBL29930818 | 0.77 | HSD17B2 (0.39) | DYRK1ADYRK1BSRCKDRFLT3 | |
| SCHEMBL29930904 | 0.76 | CLK1 (0.39) | DYRK1ADYRK1BMERTKMAPTFYN | |
| SCHEMBL3489403 | 0.76 | CHEK1 (0.38) | AAK1SRCAXLKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |