Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | MERTK | Q12866 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930815 | 0.90 | AXL (0.41) | AXLMERTKKDRSRCDYRK1B | |
| SCHEMBL1592834 | 0.89 | MERTK (0.39) | AXLMERTKAURKAKDRFLT3 | |
| SCHEMBL29930883 | 0.89 | AXL (0.42) | AXLMERTKAURKAKDRFLT3 | |
| SCHEMBL29930401 | 0.88 | DYRK1B (0.40) | AXLMERTKAURKAKDRFLT3 | |
| SCHEMBL29930809 | 0.88 | DGAT1 (0.37) | AXLMERTKAURKAKDRFLT3 | |
| SCHEMBL29930508 | 0.86 | DGAT1 (0.36) | MERTKDYRK1BPDE1BDGAT1DYRK1A | |
| SCHEMBL29930721 | 0.85 | MERTK (0.42) | MERTKDGAT1ALDH1A1KDM4EMAPT | |
| SCHEMBL29930958 | 0.85 | AXL (0.39) | AXLMERTKAURKAKDRFLT3 | |
| SCHEMBL29930865 | 0.84 | DYRK1A (0.44) | AXLMERTKAURKAKDRFLT3 | |
| SCHEMBL29930775 | 0.84 | MAPT (0.35) | DGAT1MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235097-A1 | PHARMACEUTICAL COMPOSITION CONTAINING NOVEL PYRAZOLO[3,4-B]PYRIDINE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE INCLUDING OBESITY AND DIABETES MELLITUS OR NONALCOHOLIC STEATOHEPATITIS | 한국화학연구원 | 2022-11-10 | — | — | WO | disclosed |