Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | C5 | P01031 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carprofen SCHEMBL29377449 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL30910956 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL30910972 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL3909 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL29743273 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL3698103 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL5055325 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL3910 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL30910975 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL9814869 | 0.99 | PTGS2 (0.97) | PTGS2MEN1ABCC4C5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115209878-A | Soft chewable shaped bodies for administration to animals | 拜耳动物保健有限责任公司 | 2022-10-18 | — | — | CN | disclosed |