Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | C5 | P01031 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carprofen SCHEMBL29377449 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL30910956 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL29743273 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL29930903 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL5055325 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL30910975 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL3698103 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL3910 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL30910972 | 1.00 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL9814869 | 0.99 | PTGS2 (0.97) | PTGS2MEN1ABCC4C5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 34656 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260091055-A1 | Methods of Managing Traumatic Brain Injury | UNIV EMORY (US) | 2026-04-02 | — | — | US | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| US-20260000741-A1 | METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE | ACERAGEN INC (US) | 2026-01-01 | — | — | US | claimed |
| EP-4662203-A1 | BINDARIT CONJUGATES, COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES OR DISORDERS | Translatum Medicus Inc. (CA) | 2025-12-17 | — | — | EP | claimed |
| EP-3699174-B1 | COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME | ILAB (KR) | 2025-11-12 | — | — | EP | claimed |
| EP-4615506-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | Sahin, Fikret (TR) | 2025-09-17 | — | — | EP | claimed |
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| EP-4580603-A2 | SOFT CHEWABLE FORMULATIONS WITH ACTIVE INGREDIENTS | Noble Pharma, LLC (US) | 2025-07-09 | — | — | EP | claimed |
| EP-4570317-A2 | COMPOUNDS FOR THE TREATMENT OF BOVINE OR SWINE RESPIRATORY DISEASE | Intervet International B.V. (NL) | 2025-06-18 | — | — | EP | claimed |
| US-12303519-B2 | Injectable pharmaceutical compositions comprising a cyclodextrin a hydrophobic drug, a co-solvent, and a preservative | ZOETIS SERVICES LLC (US) | 2025-05-20 | — | — | US | claimed |
| WO-1984002273-A1 | ANALGESIC COMBINATIONS | SANDOZ AG (CH) | 1984-06-21 | — | — | WO | claimed |
| EP-0111456-A1 | Analgesic combinations | Cooper, Stephen A. Dr. (US) | 1984-06-20 | — | — | EP | claimed |
| WO-1984000490-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1984-02-16 | — | — | WO | claimed |
| EP-0080047-A1 | Analgesic compositions containing an opiate alkaloid compound and a carbazole compound | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-06-01 | — | — | EP | claimed |
| EP-0006606-B1 | PROCESS FOR THE PREPARATION OF CARBAZOLES AND INTERMEDIATES THEREFOR | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-12-29 | — | — | EP | claimed |
| EP-0060445-A1 | Process for the resolution of racemates and lactone esters used in said process | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-22 | — | — | EP | claimed |
| US-4264500-A | Process of making 6-chloro-α-methyl-carbazole-2-acetic acid | HOFFMANN-LA ROCHE INC. (US) | 1981-04-28 | — | — | US | claimed |
| US-4234487-A | Process of making a carbazole acetic acid | HOFFMANN-LA ROCHE INC. (US) | 1980-11-18 | — | — | US | claimed |
| EP-0008446-A1 | Process for the preparation of carbazoles and novel carbazole derivatives utilized therein | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-03-05 | — | — | EP | claimed |
| EP-0006606-A1 | Process for the preparation of carbazoles and intermediates therefor | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-01-09 | — | — | EP | claimed |