Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23460117 | 1.00 | HRH3 (0.54) | HRH3MAPK1RAB9AALDH1A1MAPT | |
| SCHEMBL23459580 | 0.85 | NR1H4 (0.40) | HRH3RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL26139478 | 0.81 | ALDH1A1 (0.55) | RAB9AALDH1A1MAPTSMN1; SMN2GPR119 | |
| SCHEMBL17100267 | 0.81 | MAPT (0.54) | HRH3MAPK1RAB9AALDH1A1MAPT | |
| SCHEMBL22629266 | 0.80 | HRH3 (0.58) | HRH3MAPK1RAB9AMAPTNPC1 | |
| SCHEMBL24421142 | 0.80 | HRH3 (0.58) | HRH3MAPK1MAPTGPR119TGM2 | |
| SCHEMBL30680858 | 0.80 | HRH3 (0.58) | HRH3MAPK1MAPTGPR119TGM2 | |
| SCHEMBL31752976 | 0.79 | HRH3 (0.57) | HRH3MAPK1RAB9AALDH1A1MAPT | |
| SCHEMBL31722347 | 0.78 | HRH3 (0.59) | HRH3MAPK1RAB9AALDH1A1MAPT | |
| SCHEMBL14875984 | 0.78 | HRH3 (0.57) | HRH3MAPK1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557933-B | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2024-08-16 | — | — | CN | disclosed |
| WO-2023088477-A1 | MULTIFUNCTIONAL COMPOUND CAPABLE OF DEGRADING BTK KINASE, AND COMPOSITION AND USE | 杭州和正医药有限公司 | 2023-05-25 | — | — | WO | disclosed |
| CN-115557933-A | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-115003304-A | Bifunctional compounds for the degradation of BTK via the ubiquitin proteasome pathway | 纽力克斯治疗公司 | 2022-09-02 | — | — | CN | disclosed |