Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | LGMN | Q99538 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17543165 | 1.00 | ATM (0.48) | ATMFLT3POLBNPC1LGMN | |
| SCHEMBL14485084 | 0.84 | NPC1 (0.52) | NPC1LGMNRAB9ALMNAMAPT | |
| SCHEMBL30116237 | 0.83 | SMN1; SMN2 (0.43) | POLBLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL17542884 | 0.83 | SMN1; SMN2 (0.43) | POLBLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL24880834 | 0.82 | ALDH1A1 (0.46) | ATMNPC1LGMNRAB9ALMNA | |
| SCHEMBL855383 | 0.82 | ALDH1A1 (0.54) | POLBNPC1LGMNRAB9ALMNA | |
| SCHEMBL27452092 | 0.82 | SMN1; SMN2 (0.45) | NPC1LGMNRAB9AMAPTALDH1A1 | |
| SCHEMBL31312959 | 0.82 | ALDH1A1 (0.54) | POLBNPC1LGMNRAB9ALMNA | |
| SCHEMBL31342133 | 0.80 | NPC1 (0.43) | ATMFLT3POLBNPC1LGMN | |
| SCHEMBL17543845 | 0.80 | NPC1 (0.43) | ATMFLT3POLBNPC1LGMN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |