Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536056 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1SMN1; SMN2MAPT | |
| SCHEMBL23536079 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1SMN1; SMN2MAPT | |
| SCHEMBL29932012 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1SMN1; SMN2MAPT | |
| SCHEMBL23536366 | 0.90 | ALDH1A1 (0.45) | ALDH1A1KDM4ETDP1SMN1; SMN2MAPT | |
| SCHEMBL23536012 | 0.88 | ALDH1A1 (0.37) | ALDH1A1KDM4ESMN1; SMN2MAPTGAA | |
| SCHEMBL29932075 | 0.88 | ALDH1A1 (0.37) | ALDH1A1KDM4ESMN1; SMN2MAPTGAA | |
| SCHEMBL23535941 | 0.85 | ALDH1A1 (0.38) | ALDH1A1KDM4ETDP1SMN1; SMN2MAPT | |
| SCHEMBL29931922 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KDM4ETDP1SMN1; SMN2MAPT | |
| SCHEMBL23536258 | 0.82 | ALDH1A1 (0.47) | ALDH1A1KDM4ETDP1SMN1; SMN2MAPT | |
| SCHEMBL23536046 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4ETDP1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |