Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931922 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KDM4ETDP1HTTKMT2A | |
| SCHEMBL29932007 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1HTTKMT2A | |
| SCHEMBL29932012 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1HTTKMT2A | |
| SCHEMBL23536079 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1HTTKMT2A | |
| SCHEMBL23536056 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1HTTKMT2A | |
| SCHEMBL23536225 | 0.82 | CTSB (0.49) | ALDH1A1KDM4ETDP1HTTKMT2A | |
| SCHEMBL29931897 | 0.82 | CTSB (0.49) | ALDH1A1KDM4ETDP1HTTKMT2A | |
| SCHEMBL23536096 | 0.79 | MEN1 (0.56) | ALDH1A1KDM4EHTTKMT2ASMN1; SMN2 | |
| SCHEMBL23536262 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4ETDP1HTTKMT2A | |
| SCHEMBL29931992 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KDM4ETDP1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115087440-A | TRPML modulators | 卡斯玛治疗公司 | 2022-09-20 | — | — | CN | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |