Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | FBP1 | P09467 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23364834 | 1.00 | MCHR1 (0.40) | MCHR1ALDH1A1CYP3A4TDP1TLR8 | |
| SCHEMBL23364566 | 0.82 | ALDH1A1 (0.49) | ALDH1A1CYP3A4TGFBR1MAPTFBP1 | |
| SCHEMBL17414695 | 0.74 | CA1 (0.47) | MCHR1ALDH1A1CYP3A4TLR8MAPT | |
| SCHEMBL23364728 | 0.73 | MEN1 (0.45) | MCHR1ALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL29932728 | 0.73 | MEN1 (0.45) | MCHR1ALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL23364617 | 0.72 | MPL (0.52) | ALDH1A1TGFBR1MAPTFBP1LMNA | |
| SCHEMBL29932908 | 0.72 | MPL (0.52) | ALDH1A1TGFBR1MAPTFBP1LMNA | |
| SCHEMBL30588845 | 0.70 | MCHR1 (0.40) | MCHR1TLR8CA1CA2CA7 | |
| SCHEMBL26126504 | 0.70 | MCHR1 (0.40) | MCHR1TLR8CA1CA2CA7 | |
| SCHEMBL18016720 | 0.67 | MCHR1 (0.40) | MCHR1ALDH1A1CYP3A4TDP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058439-A1 | 5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY | Genzyme Corporation (US) | 2022-09-21 | — | — | EP | disclosed |
| CN-115003659-A | 5-membered heteroaryl amino sulfonamides for the treatment of conditions mediated by a deficiency in CFTR activity | 健赞公司 | 2022-09-02 | — | — | CN | disclosed |