Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RORB | Q92753 | 3/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23364617 | 1.00 | MPL (0.52) | MPLMEN1KMT2ANPC1RAB9A | |
| SCHEMBL23364566 | 0.85 | ALDH1A1 (0.49) | MPLMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL29932787 | 0.84 | MPL (0.50) | MPLMEN1KMT2ANPC1RAB9A | |
| SCHEMBL23364828 | 0.84 | MPL (0.50) | MPLMEN1KMT2ANPC1RAB9A | |
| SCHEMBL23364821 | 0.78 | MPL (0.55) | MPLMEN1KMT2ANPC1RAB9A | |
| SCHEMBL29932816 | 0.78 | MPL (0.55) | MPLMEN1KMT2ANPC1RAB9A | |
| SCHEMBL23364767 | 0.78 | MPL (0.40) | MPLMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL29932859 | 0.72 | MCHR1 (0.40) | MEN1KMT2AALDH1A1TGFBR1FBP1 | |
| SCHEMBL23364834 | 0.72 | MCHR1 (0.40) | MEN1KMT2AALDH1A1TGFBR1FBP1 | |
| SCHEMBL23364670 | 0.72 | MPL (0.60) | MPLMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058439-A1 | 5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY | Genzyme Corporation (US) | 2022-09-21 | — | — | EP | disclosed |
| CN-115003659-A | 5-membered heteroaryl amino sulfonamides for the treatment of conditions mediated by a deficiency in CFTR activity | 健赞公司 | 2022-09-02 | — | — | CN | disclosed |