SCHEMBL299335

SCHEMBL299335

O=C(O)c1ccc(-n2cncn2)c([N+](=O)[O-])c1

nearest known ligand 0.65

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.65
KMT2A Q03164 2/20 0.65
POLB P06746 1/20 0.65
MEN1 O00255 1/20 0.61
ALDH1A1 P00352 1/20 0.61
L3MBTL1 Q9Y468 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1275821 0.88 MAPT (0.64) MAPTKMT2APOLBMEN1ALDH1A1
Zinc Ion SCHEMBL28417990 0.80 MAPT (0.44) MAPTKMT2APOLBMEN1ALDH1A1
SCHEMBL7445704 0.79 MAPT (0.65) MAPTKMT2APOLBMEN1ALDH1A1
SCHEMBL16168691 0.79 POLB (0.65) MAPTKMT2APOLBMEN1ALDH1A1
SCHEMBL29758132 0.79 MAPT (0.65) MAPTKMT2APOLBMEN1ALDH1A1
SCHEMBL4254004 0.78 KMT2A (0.65) MAPTKMT2AMEN1ALDH1A1L3MBTL1
SCHEMBL12490579 0.77 CYP1A2 (0.71) MAPTKMT2APOLBMEN1ALDH1A1
SCHEMBL29664680 0.77 MYC (0.54) MAPTKMT2APOLBALDH1A1
SCHEMBL29664608 0.77 CYP1A2 (0.71) MAPTKMT2APOLBMEN1ALDH1A1
SCHEMBL18394604 0.77 MYC (0.54) MAPTKMT2APOLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8455399-B2 N-(4-perfluoroalkyl-phenyl)-4-triazolyl-benzamides as insecticides SYNGENTA CROP PROTECTION LLC (US) 2013-06-04 US disclosed
US-8455399-B2 N-(4-perfluoroalkyl-phenyl)-4-triazolyl-benzamides as insecticides SYNGENTA CROP PROTECTION LLC (US) 2013-06-04 US disclosed
US-8455399-B2 N-(4-perfluoroalkyl-phenyl)-4-triazolyl-benzamides as insecticides SYNGENTA CROP PROTECTION LLC (US) 2013-06-04 US disclosed
US-20130023571-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES SYNGENTA CROP PROTECTION LLC (US) 2013-01-24 US disclosed
US-20130023571-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES SYNGENTA CROP PROTECTION LLC (US) 2013-01-24 US disclosed
US-20130023571-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES SYNGENTA CROP PROTECTION LLC (US) 2013-01-24 US disclosed
EP-2427439-B1 N-(4-PERFLUOROALKYL-PHENYL)-4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2013-01-16 EP disclosed
EP-2427439-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES Syngenta Participations AG (CH) 2012-03-14 EP disclosed
WO-2010127927-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 WO disclosed
WO-2010127927-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 WO disclosed
US-5834471-A Amide derivatives as 5HT1D receptor antagonists SMITHKLINE BEECHAM P.L.C. (GB) 1998-11-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130023571-A1 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES PFAS, AADAC, FABP5 MAPT 3468/4885KMT2A 1668/4885POLB 4481/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.