SCHEMBL2993471

SCHEMBL2993471

FC(F)(Br)C(F)(F)Sc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.39
HPGD P15428 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
MGLL Q99685 1/20 0.39
HSD17B10 Q99714 1/20 0.39
PTPN1 P18031 2/20 0.36
PTPRZ1 P23471 2/20 0.36
ALDH1A1 P00352 4/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.35
KDM4E B2RXH2 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
KIF11 P52732 1/20 0.31
KCNK2 O95069 1/20 0.31
KCNK10 P57789 1/20 0.31
LMNA P02545 3/20 0.30
ATM Q13315 1/20 0.30
THRB P10828 1/20 0.30
KMT2A Q03164 1/20 0.30
CES1 P23141 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL776739 0.82 MAPT (0.41) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL431548 0.79 MAPT (0.43) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL25118323 0.78 SMN1; SMN2 (0.38) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL1260200 0.78 CYP2A6 (0.38) SMN1; SMN2PTPN1PTPRZ1ALDH1A1MAPK1
SCHEMBL20714602 0.78 MAPT (0.38) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL776220 0.78 ALDH1A1 (0.46) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL3989851 0.78 KDM4E (0.38) PTPN1PTPRZ1ALDH1A1KDM4ETDP1
SCHEMBL777619 0.76 ALDH1A1 (0.41) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL777056 0.76 ALDH1A1 (0.56) MAPTHPGDSMN1; SMN2MGLLHSD17B10
SCHEMBL9430594 0.75 ALDH1A1 (0.41) MAPTHPGDSMN1; SMN2MGLLHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10590091-B2 Process for the preparation of azidoperfluoroalkanes and N-polyfluoroalkyl azides Ustav Organicke Chemie A Biochemie AV CR , v.v.i. (CZ) 2020-03-17 US disclosed
US-20190161452-A1 Process for the preparation of azidoperfluoroalkanes and N-polyfluoroalkyl azides USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) 2019-05-30 US disclosed
EP-2084166-B1 PREPARATION PROCESS OF AROMATIC SULFONYLIMIDES INST NAT POLYTECHNIQUE DE GRENOBLE (FR) 2017-11-22 EP disclosed
EP-2084166-B1 PREPARATION PROCESS OF AROMATIC SULFONYLIMIDES INST NAT POLYTECHNIQUE DE GRENOBLE (FR) 2017-11-22 EP disclosed
US-8853448-B2 Aromatic sulfonylimides, preparation thereof and use thereof as electrolyte INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE (FR) 2014-10-07 US disclosed
US-8853448-B2 Aromatic sulfonylimides, preparation thereof and use thereof as electrolyte INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE (FR) 2014-10-07 US disclosed
US-8853448-B2 Aromatic sulfonylimides, preparation thereof and use thereof as electrolyte INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE (FR) 2014-10-07 US disclosed
US-20100174113-A1 AROMATIC SULPHONYLIMIDES, PREPARATION THEREOF AND USE THEREOF AS ELECTROLYTE INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE (FR) 2010-07-08 US disclosed
US-20100174113-A1 AROMATIC SULPHONYLIMIDES, PREPARATION THEREOF AND USE THEREOF AS ELECTROLYTE INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE (FR) 2010-07-08 US disclosed
US-4552984-A SULFONYLATION IN PRESENCE OF BORON TRIFLUORIDE, HYDROGEN FLUORIDE RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1985-11-12 US disclosed
EP-0084743-B1 PROCESS FOR THE PREPARATION OF ALPHA, ALPHA-DIFLUOROALKOXY OR ALPHA, ALPHADIFLUOROALKYLTHIOPHENYL SULFONES RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-11-21 EP disclosed
EP-0052559-B1 BROMOPOLYFLUORALKYLTHIOETHERS AND PROCESS FOR THEIR PREPARATION RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-10-24 EP disclosed
US-4446078-A REACTING A POLYHALOALKOXY- OR POLYHALOALKYLTHIOBENZENE WITH A CARBOXYLIC DERIVATIVE, BORON TRIFLUORIDE RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-05-01 US disclosed
EP-0084743-A1 Process for the preparation of alpha, alpha-difluoroalkoxy or alpha, alphadifluoroalkylthiophenyl sulfones RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1983-08-03 EP disclosed
EP-0052559-A2 Bromopolyfluoralkylthioethers and process for their preparation RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-05-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100174113-A1 AROMATIC SULPHONYLIMIDES, PREPARATION THEREOF AND USE THEREOF AS ELECTROLYTE AFF2, ARSA, FGFR2 MAPT 4578/4885HPGD 4844/4885SMN1; SMN2 1758/4885
US-10590091-B2 Process for the preparation of azidoperfluoroalkanes and N-polyfluoroalkyl azides CYP2F1, PRXL2A, CRBN MAPT 4866/4885HPGD 4220/4885SMN1; SMN2 3780/4885
US-20190161452-A1 Process for the preparation of azidoperfluoroalkanes and N-polyfluoroalkyl azides CYP2F1, PRXL2A, CRBN MAPT 4866/4885HPGD 4220/4885SMN1; SMN2 3780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.