Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.32 |
| ▸ | TEAD4 | Q15561 | 2/20 | 0.32 |
| ▸ | TEAD2 | Q15562 | 2/20 | 0.32 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23363723 | 1.00 | SLC5A2 (0.33) | SLC5A2GRM2TEAD1TEAD4TEAD2 | |
| SCHEMBL25064157 | 0.91 | ALDH1A1 (0.38) | SLC5A2MAPKAPK2ALDH1A1KDM4ELMNA | |
| SCHEMBL30364092 | 0.91 | ALDH1A1 (0.38) | SLC5A2MAPKAPK2ALDH1A1KDM4ELMNA | |
| SCHEMBL30460617 | 0.83 | KDM4E (0.32) | TEAD1TEAD4TEAD2TEAD3KDM4E | |
| SCHEMBL25064016 | 0.83 | KDM4E (0.32) | TEAD1TEAD4TEAD2TEAD3KDM4E | |
| SCHEMBL30460367 | 0.83 | KDM4E (0.32) | TEAD1TEAD4TEAD2TEAD3KDM4E | |
| SCHEMBL25064026 | 0.83 | KDM4E (0.32) | TEAD1TEAD4TEAD2TEAD3KDM4E | |
| SCHEMBL25064015 | 0.83 | KDM4E (0.32) | TEAD1TEAD4TEAD2TEAD3KDM4E | |
| SCHEMBL30460355 | 0.83 | KDM4E (0.32) | TEAD1TEAD4TEAD2TEAD3KDM4E | |
| SCHEMBL23363833 | 0.83 | TEAD1 (0.45) | SLC5A2TEAD1TEAD4TEAD2TEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116234797-A | Heterocyclic inhibitors of TEAD for the treatment of cancer | 基因泰克公司 | 2023-06-06 | — | — | CN | disclosed |
| EP-4185386-A1 | HETEROCYCLIC INHIBITORS OF TEAD FOR TREATING CANCER | Genentech, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |
| EP-4058435-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2022-09-21 | — | — | EP | disclosed |