Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16650823 | 1.00 | POLB (0.57) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL3708440 | 0.92 | POLB (0.52) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL15561596 | 0.83 | L3MBTL1 (0.69) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL29934976 | 0.83 | L3MBTL1 (0.69) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL192738 | 0.82 | POLB (0.67) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL29447103 | 0.82 | POLB (0.67) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL1766204 | 0.82 | NPC1 (0.46) | POLBL3MBTL1HTR2AHTR2CMAPT | |
| SCHEMBL1359709 | 0.82 | HTR2A (0.48) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL30536258 | 0.82 | HTR2A (0.48) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| Hydrochloric Acid SCHEMBL1401340 | 0.80 | POLB (0.64) | POLBL3MBTL1HTR2ATAAR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058435-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2022-09-21 | — | — | EP | disclosed |