Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29934779 | 0.92 | POLB (0.57) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL16650823 | 0.92 | POLB (0.57) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL3341643 | 0.83 | POLB (0.52) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL25095598 | 0.83 | TDP1 (0.43) | POLBL3MBTL1MAPTNPC1 | |
| SCHEMBL29447103 | 0.82 | POLB (0.67) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL1766204 | 0.82 | NPC1 (0.46) | POLBL3MBTL1HTR2AHTR2CMAPT | |
| SCHEMBL1359709 | 0.82 | HTR2A (0.48) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL192738 | 0.82 | POLB (0.67) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| SCHEMBL30536258 | 0.82 | HTR2A (0.48) | POLBL3MBTL1HTR2ATAAR1HTR2C | |
| Hydrochloric Acid SCHEMBL1401340 | 0.80 | POLB (0.64) | POLBL3MBTL1HTR2ATAAR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4744661-A2 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2026-05-20 | — | — | EP | disclosed |
| EP-4298092-B1 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-11-26 | — | — | EP | disclosed |
| EP-4626860-A1 | FUSED PYRROLYL-SULFONAMIDE COMPOUNDS | ReWind Therapeutics NV (BE) | 2025-10-08 | — | — | EP | disclosed |
| WO-2025092989-A1 | SUBSTITUTED QUINAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMBINATION THEREOF, AND USE THEREOF | 泰州红云制药有限公司 | 2025-05-08 | — | — | WO | disclosed |
| CN-118619959-A | Hydrazide compound, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2024-09-10 | — | — | CN | disclosed |
| WO-2024115733-A1 | FUSED PYRROLYL-SULFONAMIDE COMPOUNDS | REWIND THERAPEUTICS NV (BE) | 2024-06-06 | — | — | WO | disclosed |
| US-20240025883-A1 | PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-25 | — | — | US | disclosed |
| EP-4298092-A1 | NOVEL PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-01-03 | — | — | EP | disclosed |
| CN-116829550-A | Pyrimidine-2-ylsulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |
| US-11649224-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
| WO-2012064269-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF Αβ-RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-05-18 | — | — | WO | disclosed |
| US-20120122843-A1 | Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases | ASTRAZENECA AB (SE) | 2012-05-17 | — | — | US | disclosed |
| CN-1478092-A | Benzoxazinone derivatives, their preparation and use | ʷ | 2004-02-25 | — | — | CN | disclosed |
| US-5191105-A | Chemical intermediates | SUMITOMO CHEMICAL COMPANY, LTD. (JP) | 1993-03-02 | — | — | US | disclosed |
| US-5030760-A | Chemical intermediates; herbicides | SUMITOMO CHEMICAL COMPANY, LTD. (JP) | 1991-07-09 | — | — | US | disclosed |
| US-4818276-A | Herbicidal 1-aryl-Δ2 -1,2,4-triazolin-5-ones | FMC CORPORATION (US) | 1989-04-04 | — | — | US | disclosed |
| EP-0231176-A1 | HERBICIDAL 1-ARYL-$g(d)?2 -1,2,4-TRIAZOLIN-5-ONES | FMC Corporation (US) | 1987-08-12 | — | — | EP | disclosed |
| WO-1987000730-A1 | HERBICIDAL 1-ARYL-delta2-1,2,4-TRIAZOLIN-5-ONES | FMC CORPORATION (US) | 1987-02-12 | — | — | WO | disclosed |
| CN-85106905-A | Contain 1-aryl-Δ 2-1,2,4, weedicide of-triazoline-5-ketone and preparation method thereof | — | 1987-02-04 | — | — | CN | disclosed |
| US-4484940-A | Tetrahydrophthalimides, and their production and use as herbicides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122843-A1 | Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases | APP, BACE1, PSEN1 | POLB 2974/4885L3MBTL1 4304/4885HTR2A 2243/4885 |
| US-20240025883-A1 | PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | GPR17, GPR27, GPR119 | POLB 3512/4885L3MBTL1 4583/4885HTR2A 760/4885 |
| US-11649224-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | POLB 2859/4885L3MBTL1 446/4885HTR2A 4627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.