Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306952 | 1.00 | ALDH1A1 (0.44) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL10567265 | 0.93 | ALDH1A1 (0.47) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL29785367 | 0.86 | ALDH1A1 (0.44) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL12491675 | 0.86 | ALDH1A1 (0.44) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL1766175 | 0.85 | ALDH1A1 (0.58) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL31377991 | 0.85 | ALDH1A1 (0.58) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL4103425 | 0.84 | MAPT (0.49) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL30230904 | 0.84 | ALDH1A1 (0.48) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL30801468 | 0.84 | ALDH1A1 (0.48) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL4279356 | 0.84 | ALDH1A1 (0.48) | ALDH1A1TDP1MAPTKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058435-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2022-09-21 | — | — | EP | disclosed |