Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.42 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 4/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20598748 | 1.00 | DGAT1 (0.42) | DGAT1SPRTTKCFTRPDE10A | |
| SCHEMBL20617454 | 0.90 | SPR (0.34) | DGAT1SPRTTKCFTRPDE10A | |
| SCHEMBL1371876 | 0.89 | POLB (0.39) | DGAT1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL1369168 | 0.86 | DGAT1 (0.39) | DGAT1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL1696885 | 0.86 | DGAT1 (0.38) | DGAT1 | |
| SCHEMBL13858243 | 0.85 | DGAT1 (0.40) | DGAT1MAPT | |
| SCHEMBL1371873 | 0.84 | DGAT1 (0.39) | DGAT1ALDH1A1JAK3MAPT | |
| SCHEMBL1370137 | 0.83 | DGAT1 (0.38) | DGAT1MAPTKDM4E | |
| SCHEMBL1372546 | 0.82 | DGAT1 (0.41) | DGAT1ALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL14738401 | 0.82 | DGAT1 (0.39) | DGAT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288943-B1 | PYRROLO[2,3-B]PYRAZINYL ACRYLAMIDES AND EPOXIDES THEREOF AS INHIBITORS OF JANUS KINASE | PFIZER (US) | 2022-09-28 | — | — | EP | disclosed |