Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20598843 | 1.00 | GAA (0.33) | GAAOPRK1LMNANPC1RAB9A | |
| SCHEMBL29187947 | 1.00 | GAA (0.33) | GAAOPRK1LMNANPC1RAB9A | |
| SCHEMBL9532921 | 0.86 | OPRK1 (0.34) | GAAOPRK1LMNANPC1RAB9A | |
| SCHEMBL2827553 | 0.86 | OPRK1 (0.34) | GAAOPRK1LMNANPC1RAB9A | |
| SCHEMBL8359388 | 0.86 | OPRK1 (0.34) | GAAOPRK1LMNANPC1RAB9A | |
| SCHEMBL9532910 | 0.86 | OPRK1 (0.34) | GAAOPRK1LMNANPC1RAB9A | |
| SCHEMBL2847058 | 0.86 | OPRK1 (0.34) | GAAOPRK1LMNANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3114222 | 0.84 | OPRK1 (0.33) | GAAOPRK1LMNANPC1RAB9A | |
| SCHEMBL3307873 | 0.83 | — | — | |
| SCHEMBL18956885 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288943-B1 | PYRROLO[2,3-B]PYRAZINYL ACRYLAMIDES AND EPOXIDES THEREOF AS INHIBITORS OF JANUS KINASE | PFIZER (US) | 2022-09-28 | — | — | EP | disclosed |