Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23388219 | 1.00 | CHEK2 (0.43) | CHEK2MEN1KMT2ATOP2ATOP2B | |
| SCHEMBL11441506 | 0.83 | CHEK2 (0.47) | CHEK2MEN1KMT2AAKR1C2IDO1 | |
| SCHEMBL646362 | 0.80 | TOP2A (0.49) | MEN1KMT2ATOP2ATOP2BALDH1A1 | |
| SCHEMBL939618 | 0.77 | TOP2A (0.47) | MEN1KMT2ATOP2ATOP2BAKR1C2 | |
| SCHEMBL23388231 | 0.77 | APLNR (0.43) | MEN1KMT2ATOP2ATOP2BAKR1C2 | |
| SCHEMBL29936440 | 0.77 | APLNR (0.43) | MEN1KMT2ATOP2ATOP2BAKR1C2 | |
| SCHEMBL24956326 | 0.76 | HTR3E (0.47) | CHEK2PPARGPPARAAKR1C2IDO1 | |
| SCHEMBL12782118 | 0.74 | TOP2A (0.44) | MEN1KMT2ATOP2ATOP2BAKR1C2 | |
| SCHEMBL4603119 | 0.74 | TOP2A (0.51) | MEN1KMT2ATOP2ATOP2BALDH1A1 | |
| SCHEMBL23388234 | 0.73 | TRPV1 (0.47) | CHEK2PPARGPPARAAKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061347-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF ACUTE INTERMITTENT PORPHYRIA | Vestlandets Innovasjonsselskap AS (NO) | 2022-09-28 | — | — | EP | disclosed |