Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.57 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | CA9 | Q16790 | 4/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13415321 | 0.82 | TP53 (0.60) | TP53NPC1RAB9ASMN1; SMN2ACHE | |
| SCHEMBL16592595 | 0.82 | ACHE (0.57) | TP53NPC1RAB9ASMN1; SMN2ACHE | |
| SCHEMBL29936903 | 0.82 | RAB9A (0.74) | TP53NPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL26096204 | 0.81 | NR1H4 (0.70) | TP53NPC1RAB9ASMN1; SMN2ACHE | |
| SCHEMBL16592554 | 0.80 | NR1H4 (0.78) | TP53NPC1RAB9ASMN1; SMN2ACHE | |
| SCHEMBL11323465 | 0.80 | NR1H4 (0.78) | TP53NPC1RAB9ASMN1; SMN2ACHE | |
| SCHEMBL15425072 | 0.79 | TP53 (0.63) | TP53NPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL31660373 | 0.79 | TP53 (0.63) | TP53NPC1RAB9ASMN1; SMN2GRM5 | |
| SCHEMBL60606 | 0.78 | NPC1 (0.67) | TP53NPC1RAB9ASMN1; SMN2ACHE | |
| SCHEMBL31659979 | 0.76 | NPC1 (0.73) | TP53NPC1RAB9ASMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208955-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | RESEARCH TRIANGLE INSTITUTE | 2024-06-27 | — | — | US | disclosed |
| EP-4304630-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | Research Triangle Institute (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2022192126-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | RESEARCH TRIANGLE INSTITUTE (US) | 2022-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208955-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | RXFP3, RXFP1, RXFP4 | TP53 4821/4885NPC1 4471/4885RAB9A 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.