Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | BRAF | P15056 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242724 | 1.00 | KDR (0.53) | KDRBRAFHPGDALDH1A1KDM4E | |
| SCHEMBL16311225 | 0.85 | KDR (0.52) | KDRBRAFHPGDALDH1A1KDM4E | |
| SCHEMBL15652065 | 0.84 | MAPK14 (0.45) | KDRBRAFALDH1A1KDM4ENPC1 | |
| SCHEMBL5208827 | 0.81 | P4HTM (0.42) | KDRKDM4C | |
| SCHEMBL21018215 | 0.80 | ALDH1A1 (0.47) | KDRHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL6611571 | 0.79 | ALDH1A1 (0.49) | HPGDALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL163711 | 0.78 | KDR (0.48) | KDRBRAFHPGDALDH1A1KDM4E | |
| SCHEMBL8922592 | 0.78 | KDM4E (0.57) | ALDH1A1KDM4ENPC1LMNAMAPT | |
| SCHEMBL15574523 | 0.77 | KDR (0.58) | KDRBRAFRAF1EPHX2 | |
| SCHEMBL171083 | 0.77 | CTSA (0.48) | KDRBRAFNPC1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313292-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022200576-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | disclosed |