Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 4/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | PANK3 | Q9H999 | 5/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 2/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22754620 | 0.91 | JAK1 (0.46) | KDM4EALDH1A1L3MBTL1JAK1JAK2 | |
| Hydrochloric Acid SCHEMBL21522335 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1L3MBTL1JAK1JAK2 | |
| SCHEMBL1728173 | 0.84 | GPR119 (0.47) | KDM4EALDH1A1L3MBTL1JAK1JAK2 | |
| SCHEMBL1728176 | 0.84 | GPR119 (0.47) | KDM4EALDH1A1L3MBTL1JAK1JAK2 | |
| SCHEMBL12153075 | 0.84 | GPR119 (0.47) | KDM4EALDH1A1L3MBTL1JAK1JAK2 | |
| SCHEMBL2306277 | 0.84 | GPR119 (0.47) | KDM4EALDH1A1L3MBTL1JAK1JAK2 | |
| SCHEMBL16478649 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1L3MBTL1JAK1JAK2 | |
| SCHEMBL16718810 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1L3MBTL1JAK1JAK2 | |
| SCHEMBL12683422 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1L3MBTL1JAK1JAK2 | |
| Hydrochloric Acid SCHEMBL21522334 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1L3MBTL1JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308229-A1 | INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117396469-A | Inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022197763-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |