Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29277941 | 0.93 | RXFP1 (0.44) | ALOX15HTTPSMD14PSMB5HPGDS | |
| SCHEMBL19780100 | 0.89 | HTT (0.55) | ALOX15HTTPSMB5MAPK1PDGFRB | |
| SCHEMBL29940558 | 0.89 | HTT (0.55) | ALOX15HTTPSMB5MAPK1PDGFRB | |
| SCHEMBL29277914 | 0.83 | HTT (0.48) | ALOX15HTTPSMB5PDGFRBPDGFRA | |
| SCHEMBL10466162 | 0.82 | HTT (0.67) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL1644304 | 0.80 | MAPK1 (0.41) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL264087 | 0.80 | PTPN11 (0.51) | ALOX15HTTNPC1HSP90AA1RAB9A | |
| SCHEMBL31250404 | 0.79 | ALOX15 (0.54) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL1353856 | 0.79 | ALOX15 (0.54) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL20118976 | 0.79 | ALOX15 (0.54) | ALOX15HTTPSMD14HPGDSMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308229-A1 | INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197763-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |