Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19780100 | 1.00 | HTT (0.55) | HTTALOX15PSMB5PDGFRBPDGFRA | |
| SCHEMBL29277914 | 0.93 | HTT (0.48) | HTTALOX15PSMB5PDGFRBPDGFRA | |
| SCHEMBL29940332 | 0.89 | ALOX15 (0.48) | HTTALOX15PSMB5PDGFRBPDGFRA | |
| SCHEMBL21355246 | 0.86 | NPC1 (0.51) | HTTPSMB5PDGFRBPDGFRANPC1 | |
| SCHEMBL29278003 | 0.83 | ALOX15 (0.39) | HTTALOX15PSMB5PDGFRBPDGFRA | |
| SCHEMBL29277941 | 0.83 | RXFP1 (0.44) | HTTALOX15PSMB5MAPK1NR1H4 | |
| SCHEMBL10466162 | 0.82 | HTT (0.67) | HTTALOX15NPC1RAB9AALDH1A1 | |
| SCHEMBL18369672 | 0.82 | KLKB1 (0.51) | — | |
| SCHEMBL1644304 | 0.80 | MAPK1 (0.41) | HTTALOX15PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL264087 | 0.80 | PTPN11 (0.51) | HTTALOX15NPC1RAB9AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308229-A1 | INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197763-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |