Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29278006 | 1.00 | KDM4E (0.41) | KDM4EPSMD14ALDH1A1PDGFRBPDGFRA | |
| SCHEMBL21358450 | 0.86 | CYP2C9 (0.40) | KDM4EALDH1A1HSD17B10LMNACA12 | |
| SCHEMBL23958818 | 0.85 | PDGFRB (0.45) | KDM4EPSMD14ALDH1A1PDGFRBPDGFRA | |
| SCHEMBL17442622 | 0.80 | ATM (0.51) | KDM4EPSMD14ALDH1A1ATMALOX15 | |
| SCHEMBL29940558 | 0.76 | HTT (0.55) | KDM4EALDH1A1PDGFRBPDGFRACYP11B1 | |
| SCHEMBL19780100 | 0.76 | HTT (0.55) | KDM4EALDH1A1PDGFRBPDGFRACYP11B1 | |
| SCHEMBL29278003 | 0.74 | ALOX15 (0.39) | KDM4EALDH1A1PDGFRBPDGFRAATM | |
| SCHEMBL17067735 | 0.73 | ATM (0.57) | KDM4EALDH1A1ATMHSD17B10CYP11B1 | |
| SCHEMBL23196216 | 0.73 | PDGFRB (0.46) | KDM4EPDGFRBPDGFRAHTTLMNA | |
| SCHEMBL29939947 | 0.72 | HSD17B10 (0.35) | KDM4EALDH1A1ATMHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308229-A1 | INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197763-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |