Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.55 |
| ▸ | CFTR | P13569 | 6/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24065786 | 1.00 | NOTUM (0.56) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL18382142 | 0.89 | SOS1 (0.50) | NOTUMSOS1CFTRPTPN2NPSR1 | |
| SCHEMBL28921143 | 0.88 | SOS1 (0.49) | NOTUMSOS1CFTRPTPN2NPSR1 | |
| SCHEMBL20471822 | 0.84 | NOTUM (0.56) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL29835141 | 0.84 | NOTUM (0.60) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL20150029 | 0.84 | NOTUM (0.60) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL16647670 | 0.83 | PTPN2 (0.43) | NOTUMSOS1PTPN2NPSR1KDM4E | |
| SCHEMBL23526150 | 0.83 | NOTUM (0.55) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL3533161 | 0.83 | CFTR (0.68) | NOTUMSOS1CFTRMAPTKDM4E | |
| SCHEMBL23525884 | 0.83 | SOS1 (0.57) | NOTUMSOS1CFTRPTPN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11498915-B2 | TrkA Inhibitor | ELI LILLY AND COMPANY (US) | 2022-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11498915-B2 | TrkA Inhibitor | NGF, NGFR, OPRL1 | NOTUM 3683/4885SOS1 2669/4885CFTR 4371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.