Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523378 | 1.00 | CES2 (0.43) | CES2CES1LMNAP4HTMNAPRT | |
| SCHEMBL450118 | 0.83 | CES2 (0.46) | CES2CES1LMNAP4HTMNAPRT | |
| SCHEMBL11865903 | 0.83 | CES2 (0.46) | CES2CES1LMNAP4HTMNAPRT | |
| SCHEMBL101751 | 0.81 | LMNA (0.48) | CES2CES1LMNAP4HTMNAPRT | |
| SCHEMBL3676096 | 0.81 | CES2 (0.45) | CES2CES1LMNAP4HTMNAPRT | |
| SCHEMBL28960343 | 0.81 | CES2 (0.45) | CES2CES1LMNAP4HTMNAPRT | |
| SCHEMBL7351837 | 0.79 | CES2 (0.43) | CES2CES1LMNAP4HTMNAPRT | |
| SCHEMBL7521569 | 0.79 | CES2 (0.48) | CES2CES1LMNAP4HTMNAPRT | |
| SCHEMBL253858 | 0.79 | CES2 (0.43) | CES2CES1LMNAP4HTMNAPRT | |
| SCHEMBL519065 | 0.79 | CES2 (0.43) | CES2CES1LMNAP4HTMNAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308552-A2 | DERIVATIVES OF SUBSTITUTED MORPHOLINES AND USES THEREOF | Supernus Pharmaceuticals, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022198062-A2 | DERIVATIVES OF SUBSTITUTED MORPHOLINES AND USES THEREOF | SUPERNUS PHARMACEUTICALS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |