Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23526034 | 1.00 | PRMT5 (0.49) | PRMT5WDR77CASP3PIK3R1PIK3CA | |
| SCHEMBL23914628 | 0.93 | PRMT5 (0.46) | PRMT5WDR77CASP3PIK3R1PIK3CA | |
| SCHEMBL29735211 | 0.93 | PRMT5 (0.46) | PRMT5WDR77CASP3PIK3R1PIK3CA | |
| SCHEMBL25839255 | 0.81 | CHEK1 (0.44) | PRMT5WDR77TYMSCHEK1PIM1 | |
| SCHEMBL2460969 | 0.79 | PRMT5 (0.49) | PRMT5WDR77PIK3R1PIK3CATYMS | |
| SCHEMBL26732571 | 0.79 | PRMT5 (0.49) | PRMT5WDR77TYMSJAK2CHEK1 | |
| SCHEMBL30984825 | 0.79 | PRMT5 (0.49) | PRMT5WDR77TYMSJAK2CHEK1 | |
| SCHEMBL14826495 | 0.78 | ADORA2A (0.42) | PRMT5WDR77DYRK1AAURKAACVR1 | |
| SCHEMBL17824579 | 0.78 | PRMT5 (0.46) | PRMT5WDR77TYMSJAK2CHEK1 | |
| SCHEMBL17825064 | 0.78 | PRMT5 (0.59) | PRMT5WDR77GSK3BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119462626-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-115135315-B | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2024-11-26 | — | — | CN | disclosed |
| EP-4337662-A1 | C-LINKED INHIBITORS OF ENL/AF9 YEATS | Bridge Medicines (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240830-A1 | C-LINKED INHIBITORS OF ENL/AF9 YEATS | BRIDGE MEDICINES (US) | 2022-11-17 | — | — | WO | disclosed |
| CN-115135315-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2022-09-30 | — | — | CN | disclosed |