Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.37 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.37 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24000186 | 0.92 | CHEK1 (0.44) | CHEK1PARP1PIM1RPS6KA3LMNA | |
| SCHEMBL2460340 | 0.81 | CHEK1 (0.42) | CHEK1PARP1PIM1RPS6KA3LMNA | |
| SCHEMBL29945916 | 0.81 | PRMT5 (0.49) | CHEK1PIM1RPS6KA3LMNAPRMT5 | |
| SCHEMBL23526034 | 0.81 | PRMT5 (0.49) | CHEK1PIM1RPS6KA3LMNAPRMT5 | |
| SCHEMBL14826495 | 0.81 | ADORA2A (0.42) | CYP1A2LMNAPRMT5WDR77DYRK1A | |
| SCHEMBL266471 | 0.79 | PARP1 (0.44) | PARP1ALDH1A1PRMT5WDR77 | |
| SCHEMBL2308673 | 0.79 | DYRK1A (0.59) | LMNAALDH1A1DYRK1ADRD1 | |
| SCHEMBL25746121 | 0.78 | CHEK1 (0.42) | CHEK1PARP1PIM1RPS6KA3LMNA | |
| SCHEMBL2460305 | 0.78 | CHEK1 (0.42) | CHEK1PARP1PIM1RPS6KA3LMNA | |
| SCHEMBL555280 | 0.78 | ATM (0.57) | PARP1CYP1A2LMNAALDH1A1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702418-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702418-B2 | SOS1 inhibitors | SOS1, SOS2, SOST | CHEK1 1519/4885PARP1 4015/4885PIM1 1391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.