Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5174804 | 0.82 | NPC1 (0.42) | NPC1RAB9AKMT2AHSPA5SMN1; SMN2 | |
| SCHEMBL3462828 | 0.80 | GAA (0.52) | NPC1RAB9AKMT2ASMN1; SMN2GAA | |
| SCHEMBL4433086 | 0.79 | NPC1 (0.40) | NPC1RAB9AKMT2AHSPA5SMN1; SMN2 | |
| SCHEMBL7288668 | 0.79 | NPC1 (0.40) | NPC1RAB9AKMT2AHSPA5SMN1; SMN2 | |
| SCHEMBL5202785 | 0.79 | — | — | |
| Benzene SCHEMBL5151418 | 0.78 | NPC1 (0.46) | NPC1RAB9AKMT2AHSPA5SMN1; SMN2 | |
| SCHEMBL9682958 | 0.78 | SMN1; SMN2 (0.47) | NPC1RAB9AKMT2AHSPA5SMN1; SMN2 | |
| SCHEMBL1822218 | 0.78 | — | — | |
| SCHEMBL1857157 | 0.78 | — | — | |
| SCHEMBL2213386 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11578053-B2 | Chemical process for preparing phenylpiperidinyl indole derivatives | NOVARTIS AG (CH) | 2023-02-14 | — | — | US | disclosed |
| US-20220169630-A1 | CHEMICAL PROCESS FOR PREPARING PHENYLPIPERIDINYL INDOLE DERIVATIVES | NOVARTIS AG (CH) | 2022-06-02 | — | — | US | disclosed |
| US-11208398-B2 | Chemical process for preparing phenylpiperidinyl indole derivatives | NOVARTIS AG (CH) | 2021-12-28 | — | — | US | disclosed |
| US-8252954-B2 | Processes for the preparation of calixarene derivatives | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100185022-A1 | PROCESSES FOR THE PREPARATION OF CALIXARENE DERIVATIVES | THE UNIVERSITY OF WESTERN AUSTRALIA (AU) | 2010-07-22 | — | — | US | disclosed |
| US-7572898-B2 | Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside | SCINOPHARM TAIWAN, LTD. (TW) | 2009-08-11 | — | — | US | disclosed |
| US-7470784-B2 | Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine | SOUTHERN RESEARCH INSTITUTE (US) | 2008-12-30 | — | — | US | disclosed |
| WO-2008148168-A1 | PROCESSES FOR THE PREPARATION OF CALIXARENE DERIVATIVES | THE UNIVERSITY OF WESTERN AUSTRALIA (AU) | 2008-12-11 | — | — | WO | disclosed |
| EP-1891087-A4 | PROCESS OF MAKING AN ALPHA-ANOMER ENRICHED 2-DEOXY-2,2-DIFLOURO-D-RIBOFURANOSYL SULFONATE AND USE THEREOF FOR MAKING A BETA NUCLEOSIDE | SCINOPHARM TAIWAN LTD (TW) | 2008-07-30 | — | — | EP | disclosed |
| EP-1891087-A1 | PROCESS OF MAKING AN ALPHA-ANOMER ENRICHED 2-DEOXY-2,2-DIFLOURO-D-RIBOFURANOSYL SULFONATE AND USE THEREOF FOR MAKING A BETA NUCLEOSIDE | ScinoPharm Taiwan, Ltd. (TW) | 2008-02-27 | — | — | EP | disclosed |
| EP-0577302-A1 | Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates | ELI LILLY AND COMPANY (US) | 1994-01-05 | — | — | EP | disclosed |
| EP-0577304-A1 | Stereoselective anion glycosylation process | ELI LILLY AND COMPANY (US) | 1994-01-05 | — | — | EP | disclosed |
| EP-0577303-A1 | Stereoselective glycosylation process | ELI LILLY AND COMPANY (US) | 1994-01-05 | — | — | EP | disclosed |
| EP-0576232-A1 | Process for separating 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate anomers | ELI LILLY AND COMPANY (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0576229-A1 | Low temperature process for preparing alpha-anomer enriched 2-deoxy-2, 2-difluoro-D-ribofuranosyl sulfonates | ELI LILLY AND COMPANY (US) | 1993-12-29 | — | — | EP | disclosed |
| EP-0576231-A1 | Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2, 2-difluoro-D-ribofuranosyl derivatives | ELI LILLY AND COMPANY (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5256798-A | Treating beta-anomer ribofuranosyl sulfonate with source of conjugate anion | ELI LILLY AND COMPANY (US) | 1993-10-26 | — | — | US | disclosed |
| US-5256797-A | Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers | ELI LILLY AND COMPANY (US) | 1993-10-26 | — | — | US | disclosed |
| EP-0493508-A1 | NOVEL PEPTIDES ASSOCIATED WITH THE CD4 BINDING REGION OF GP120 AND THEIR METHODS OF USE | IDEC PHARMACEUTICALS CORPORATION (US) | 1992-07-08 | — | — | EP | disclosed |
| WO-1991004273-A2 | NOVEL PEPTIDES ASSOCIATED WITH THE CD4 BINDING REGION OF GP120 AND THEIR METHODS OF USE | IDEC PHARMACEUTICALS CORP. (US) | 1991-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169630-A1 | CHEMICAL PROCESS FOR PREPARING PHENYLPIPERIDINYL INDOLE DERIVATIVES | IDO1, CYP3A7, PAH | NPC1 1271/4885RAB9A 1690/4885KMT2A 971/4885 |
| US-11208398-B2 | Chemical process for preparing phenylpiperidinyl indole derivatives | CYP3A7, CYP3A5, IDO1 | NPC1 1294/4885RAB9A 1824/4885KMT2A 1019/4885 |
| US-20100185022-A1 | PROCESSES FOR THE PREPARATION OF CALIXARENE DERIVATIVES | CALD1, CANX, CALU | NPC1 1213/4885RAB9A 1164/4885KMT2A 4773/4885 |
| US-11578053-B2 | Chemical process for preparing phenylpiperidinyl indole derivatives | IDO1, CYP3A7, PAH | NPC1 1271/4885RAB9A 1690/4885KMT2A 971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.