Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2994680 | 0.80 | NPC1 (0.47) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL6037444 | 0.80 | KMT2A (0.46) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL653441 | 0.79 | RAB9A (0.69) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| Benzene SCHEMBL5151418 | 0.79 | NPC1 (0.46) | GAASMN1; SMN2KDM4EALDH1A1RAB9A | |
| SCHEMBL7444006 | 0.78 | RAB9A (0.50) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL7670441 | 0.76 | NPC1 (0.52) | SMN1; SMN2HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL76489 | 0.75 | ALDH1A1 (0.67) | GAASMN1; SMN2KDM4EALDH1A1RAB9A | |
| SCHEMBL5174804 | 0.75 | NPC1 (0.42) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL15689594 | 0.75 | GAA (0.69) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL6825870 | 0.75 | NPC1 (0.54) | GAASMN1; SMN2HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795448-B2 | Imidazoyl-benzamide anti-cancer agents | CYTOKINETICS, INCORPORATED (US) | 2010-09-14 | — | — | US | disclosed |
| US-7582668-B2 | Imidazoyl-benzamide anti-cancer agents | CYTOKINETICS, INCORPORATED (US) | 2009-09-01 | — | — | US | disclosed |