Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.46 |
| ▸ | GNPAT | O15228 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | NPY4R | P50391 | 10/20 | 0.40 |
| ▸ | NPY1R | P25929 | 7/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.40 |
| ▸ | NPY2R | P49146 | 3/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29947121 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL29947100 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL29947125 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL29947066 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL29947174 | 0.96 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL29947289 | 0.95 | KDM4E (0.49) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL6756643 | 0.95 | SMN1; SMN2 (0.50) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL29947294 | 0.93 | NPY4R (0.49) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL29947120 | 0.93 | NPY4R (0.49) | SMN1; SMN2KDM4EMAPTTHRBALOX15 | |
| SCHEMBL1718474 | 0.92 | GNPAT (0.53) | SMN1; SMN2KDM4EMAPTTHRBALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12365706-B2 | Macrocyclic peptides as potent inhibitors of K-RAS G12D mutant | MERCK SHARP & DOHME LLC (US) | 2025-07-22 | — | — | US | disclosed |
| US-20230083431-A1 | MACROCYCLIC PEPTIDES AS POTENT INHIBITORS OF K-RAS G12D MUTANT | MERCK SHARP & DOHME LLC (US) | 2023-03-16 | — | — | US | disclosed |
| EP-4076493-A1 | MACROCYCLIC PEPTIDES AS POTENT INHIBITORS OF K-RAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12365706-B2 | Macrocyclic peptides as potent inhibitors of K-RAS G12D mutant | KRAS, NRAS, HRAS | SMN1; SMN2 1207/4885KDM4E 2472/4885MAPT 4728/4885 |
| US-20230083431-A1 | MACROCYCLIC PEPTIDES AS POTENT INHIBITORS OF K-RAS G12D MUTANT | KRAS, NRAS, HRAS | SMN1; SMN2 1207/4885KDM4E 2472/4885MAPT 4728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.