Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNPAT | O15228 | 2/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.50 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPY4R | P50391 | 10/20 | 0.43 |
| ▸ | NPY1R | P25929 | 7/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.43 |
| ▸ | NPY2R | P49146 | 3/20 | 0.43 |
| ▸ | ALB | P02768 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29454444 | 1.00 | GNPAT (0.53) | GNPATSIRT5SIRT6SIRT1FOLH1 | |
| SCHEMBL31094973 | 1.00 | GNPAT (0.53) | GNPATSIRT5SIRT6SIRT1FOLH1 | |
| SCHEMBL29655002 | 1.00 | GNPAT (0.53) | GNPATSIRT5SIRT6SIRT1FOLH1 | |
| SCHEMBL1705359 | 0.96 | GNPAT (0.50) | GNPATSIRT5SIRT6SIRT1FOLH1 | |
| SCHEMBL30526285 | 0.94 | FOLH1 (0.49) | GNPATSIRT5SIRT6SIRT1FOLH1 | |
| SCHEMBL6026003 | 0.94 | FOLH1 (0.49) | GNPATSIRT5SIRT6SIRT1FOLH1 | |
| SCHEMBL468901 | 0.94 | FOLH1 (0.49) | GNPATSIRT5SIRT6SIRT1FOLH1 | |
| SCHEMBL446929 | 0.94 | FOLH1 (0.49) | GNPATSIRT5SIRT6SIRT1FOLH1 | |
| SCHEMBL29396582 | 0.94 | SIRT6 (0.56) | GNPATSIRT5SIRT6SIRT1FOLH1 | |
| SCHEMBL29397145 | 0.94 | SIRT6 (0.56) | GNPATSIRT5SIRT6SIRT1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112154145-B | Piperazine azaspiro derivatives | 辉瑞大药厂 | 2023-10-17 | — | — | CN | disclosed |
| CN-107787322-B | Tricyclic compounds and their use as phosphodiesterase inhibitors | 辉瑞大药厂 | 2023-07-07 | — | — | CN | disclosed |
| CN-110944998-B | Dihydro-pyrrolo-pyridine derivatives | 辉瑞大药厂 | 2022-08-16 | — | — | CN | disclosed |
| CN-105121439-A | Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders | PFIZER | 2015-12-02 | — | — | CN | disclosed |
| CN-104662021-A | Novel bicyclic pyridinones | PFIZER | 2015-05-27 | — | — | CN | disclosed |
| CN-102292340-B | Amino-heterocyclic compounds used as pde9 inhibitors | PFIZER | 2015-05-06 | — | — | CN | disclosed |
| CN-101687876-B | Amino-heterocyclic compounds | PFIZER | 2012-12-12 | — | — | CN | disclosed |
| EP-2152712-B1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER (US) | 2012-01-11 | — | — | EP | disclosed |
| CN-102292340-A | Amino-heterocyclic compounds used as PDE9 inhibitors | — | 2011-12-21 | — | — | CN | disclosed |
| EP-2389382-A1 | Amino-heterocyclic compounds used as pde9 inhibitors | Pfizer Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-8041687-B2 | Dynamic generation of XML Schema for backend driven data validation | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |
| US-7964607-B2 | Pyrazolo[3,4-d]pyrimidine compounds | PFIZER INC. (US) | 2011-06-21 | — | — | US | disclosed |
| CN-101687876-A | amino-heterocyclic compounds | PFIZER | 2010-03-31 | — | — | CN | disclosed |