Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CLCN2 | P51788 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | FABP2 | P12104 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23213504 | 1.00 | TDP1 (0.47) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL18529850 | 0.86 | TDP1 (0.52) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL1893739 | 0.83 | ALDH1A1 (0.56) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL6646160 | 0.82 | TDP1 (0.52) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL27544371 | 0.81 | TDP1 (0.51) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| Ammonia Solution, Strong SCHEMBL27937320 | 0.81 | ALDH1A1 (0.55) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL1919502 | 0.81 | TDP1 (0.50) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL20516073 | 0.80 | TDP1 (0.46) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL9539450 | 0.80 | ALDH1A1 (0.46) | TDP1MAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL27598132 | 0.80 | TDP1 (0.46) | TDP1MAPTALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313047-A1 | PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS | Monte Rosa Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022200857-A1 | PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-09-29 | — | — | WO | disclosed |