Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 11/20 | 0.38 |
| ▸ | BRD2 | P25440 | 5/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28668128 | 1.00 | GPR119 (0.39) | GPR119NR3C1BRD4BRD2BRD3 | |
| SCHEMBL28672015 | 0.87 | NR3C1 (0.42) | NR3C1BRD4BRD2BRD3CYP3A4 | |
| SCHEMBL28671997 | 0.79 | BRD4 (0.37) | GPR119NR3C1BRD4BRD2BRD3 | |
| SCHEMBL29947992 | 0.79 | BRD4 (0.37) | GPR119NR3C1BRD4BRD2BRD3 | |
| SCHEMBL28676062 | 0.78 | CHRM4 (0.42) | GPR119BRD4CHRM4DRD2HTR7 | |
| SCHEMBL32690051 | 0.76 | CHRM4 (0.42) | GPR119BRD4CHRM4DRD2HTR7 | |
| SCHEMBL6647243 | 0.70 | NOTUM (0.44) | GPR119CHRM4DRD2HTR7 | |
| SCHEMBL30804525 | 0.70 | NOTUM (0.44) | GPR119CHRM4DRD2HTR7 | |
| SCHEMBL19962694 | 0.70 | KDM4E (0.44) | GPR119BRD4CHRM4DRD2HTR7 | |
| SCHEMBL22868066 | 0.70 | KDM4E (0.41) | GPR119BRD4CHRM4DRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113896725-B | Pyrazoloquinoline compound and preparation method and application thereof | 沈阳药科大学 | 2022-10-25 | — | — | CN | disclosed |