Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23555263 | 0.83 | ALDH1A1 (0.39) | KMT2APOLBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL23536282 | 0.81 | RECQL (0.54) | KMT2APOLBSMN1; SMN2KDM4ETSHR | |
| SCHEMBL29931917 | 0.81 | MCOLN2 (0.35) | LMNA | |
| SCHEMBL29948520 | 0.80 | KDM4E (0.54) | KMT2APOLBSMN1; SMN2KDM4ETSHR | |
| SCHEMBL23536343 | 0.80 | KDM4E (0.54) | KMT2APOLBSMN1; SMN2KDM4ETSHR | |
| SCHEMBL29948481 | 0.80 | SMN1; SMN2 (0.49) | KMT2APOLBSMN1; SMN2KDM4ETSHR | |
| SCHEMBL23536337 | 0.80 | SMN1; SMN2 (0.49) | KMT2APOLBSMN1; SMN2KDM4ETSHR | |
| SCHEMBL14804205 | 0.78 | KDM4E (0.64) | KMT2APOLBSMN1; SMN2KDM4ETSHR | |
| SCHEMBL23536141 | 0.77 | MEN1 (0.34) | KDM4EMEN1L3MBTL1LMNA | |
| SCHEMBL14804206 | 0.73 | TSHR (0.67) | KMT2APOLBSMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076423-A1 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2021127337-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |