Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 14/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23390435 | 1.00 | TRPV4 (0.40) | TRPV4TRPM8KCNH2HSD11B1KDM4E | |
| SCHEMBL29948936 | 0.88 | TRPV4 (0.43) | TRPV4TRPM8KCNH2 | |
| SCHEMBL23390390 | 0.88 | TRPV4 (0.43) | TRPV4TRPM8KCNH2 | |
| SCHEMBL28865063 | 0.86 | TRPV4 (0.42) | TRPV4TRPM8KCNH2HSD11B1KDM4E | |
| SCHEMBL29948981 | 0.83 | TRPV4 (0.54) | TRPV4TRPM8KCNH2 | |
| SCHEMBL23390342 | 0.83 | TRPV4 (0.54) | TRPV4TRPM8KCNH2 | |
| SCHEMBL28865060 | 0.80 | TRPV4 (0.40) | TRPV4TRPM8KCNH2HSD11B1KDM4E | |
| SCHEMBL23424682 | 0.77 | MAPT (0.47) | TRPV4TRPM8KCNH2ALDH1A1POLB | |
| SCHEMBL29948746 | 0.77 | MAPT (0.47) | TRPV4TRPM8KCNH2ALDH1A1POLB | |
| SCHEMBL23390433 | 0.76 | TRPV4 (0.55) | TRPV4TRPM8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061124-A1 | TRPV4 RECEPTOR LIGANDS | University of Utah Research Foundation (US) | 2022-09-28 | — | — | EP | disclosed |