Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 5/20 | 0.55 |
| ▸ | ESR1 | P03372 | 5/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR1E | P28566 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21465756 | 1.00 | ESR2 (0.55) | ESR2ESR1TMEM97SIGMAR1NR1H2 | |
| SCHEMBL3874751 | 0.88 | ESR2 (0.61) | ESR2ESR1TMEM97SIGMAR1NR1H2 | |
| SCHEMBL38664500 | 0.86 | ABHD6 (0.56) | TMEM97SIGMAR1NR1H2HRH3LMNA | |
| SCHEMBL8440118 | 0.86 | NR1H2 (0.62) | TMEM97SIGMAR1NR1H2HRH3LMNA | |
| SCHEMBL30097032 | 0.84 | TMEM97 (0.45) | ESR2TMEM97SIGMAR1NR1H2HRH3 | |
| SCHEMBL30647004 | 0.84 | PRMT5 (0.55) | SMN1; SMN2TSHR | |
| SCHEMBL15355387 | 0.84 | PRMT5 (0.55) | SMN1; SMN2TSHR | |
| SCHEMBL38662736 | 0.83 | SGPL1 (0.47) | TMEM97SIGMAR1NR1H2HRH3HRH2 | |
| SCHEMBL30130837 | 0.83 | DPP7 (0.48) | TMEM97SIGMAR1LMNASMN1; SMN2HRH2 | |
| SCHEMBL8264660 | 0.81 | ABHD6 (0.56) | ESR2ESR1TMEM97SIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337207-A1 | COMPOUNDS AND METHODS FOR YAP/TEAD MODULATION AND INDICATIONS THEREFOR | Opna Bio SA (CH) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240966-A1 | COMPOUNDS AND METHODS FOR YAP/TEAD MODULATION AND INDICATIONS THEREFOR | OPNA IMMUNO-ONCOLOGY SA (CH) | 2022-11-17 | — | — | WO | disclosed |