Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.55 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30647004 | 1.00 | PRMT5 (0.55) | PRMT5WDR77NOTUMHPGDTSHR | |
| SCHEMBL30023801 | 0.92 | NOTUM (0.58) | PRMT5WDR77NOTUMHPGDTSHR | |
| SCHEMBL16268868 | 0.87 | ALDH1A1 (0.64) | PRMT5WDR77NOTUMHPGDTSHR | |
| SCHEMBL13261239 | 0.85 | NAMPT (0.55) | NOTUMTSHRSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL9852991 | 0.85 | SMN1; SMN2 (0.62) | PRMT5WDR77NOTUMHPGDTSHR | |
| SCHEMBL21465756 | 0.84 | ESR2 (0.55) | TSHRSMN1; SMN2 | |
| SCHEMBL29950440 | 0.84 | ESR2 (0.55) | TSHRSMN1; SMN2 | |
| SCHEMBL38664500 | 0.83 | ABHD6 (0.56) | SMN1; SMN2ABHD6NPC1RAB9AMAPT | |
| SCHEMBL8264660 | 0.83 | ABHD6 (0.56) | SMN1; SMN2ABHD6NPC1RAB9AMAPT | |
| SCHEMBL3653540 | 0.83 | NR1H2 (0.56) | TSHRSMN1; SMN2ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575158-B2 | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-11-05 | — | — | US | disclosed |
| CN-101142194-B | Benzazole derivatives, compositions, and methods of use as b-secretase inhibitors | TRANSTECH PHARMA INC | 2012-10-10 | — | — | CN | disclosed |
| CN-101142194-A | Benzazole derivatives, compositions, and methods of use as b-secretase inhibitors | TRANSTECH PHARMA INC (US) | 2008-03-12 | — | — | CN | disclosed |