Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 5/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | APOL1 | O14791 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CTSV | O60911 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562664 | 1.00 | MPL (0.33) | MPLGCGRMAPK14APOL1NOS3 | |
| SCHEMBL2562293 | 0.85 | PTGS2 (0.36) | MPLAPOL1SMN1; SMN2ERN1 | |
| SCHEMBL2561242 | 0.85 | APOL1 (0.40) | MAPK14APOL1PARP1PARP3LMNA | |
| SCHEMBL15332657 | 0.84 | CNR1 (0.39) | GCGRMAPK14CTSVCTSL | |
| SCHEMBL15331079 | 0.83 | PARP1 (0.35) | APOL1NOS3NOS2PARP1PARP3 | |
| SCHEMBL2561583 | 0.82 | EIF4A3 (0.36) | GCGRMAPK14APOL1NOS3NOS2 | |
| SCHEMBL29954926 | 0.81 | GCGR (0.34) | GCGRMAPK14CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL15331517 | 0.81 | PARP1 (0.36) | MPLMAPK14APOL1ERN1PARP1 | |
| SCHEMBL29952478 | 0.81 | APOL1 (0.44) | APOL1 | |
| SCHEMBL2554353 | 0.80 | ERN1 (0.34) | NPC1RAB9ASMN1; SMN2CTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |