SCHEMBL29951645

SCHEMBL29951645

N#Cc1cc(C=O)cc(C=O)c1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 2/20 0.38
EGFR P00533 2/20 0.37
FBP1 P09467 4/20 0.36
TTR P02766 2/20 0.36
ALB P02768 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
GPR35 Q9HC97 1/20 0.33
PTGS1 P23219 1/20 0.33
PTGS2 P35354 1/20 0.33
CA1 P00915 2/20 0.32
CA2 P00918 2/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2161087 0.95 VCAM1 (0.38) VCAM1EGFRFBP1TTRALB
SCHEMBL29952978 0.84 CYP2A6 (0.38) VCAM1FBP1TTRALBPTGS1
SCHEMBL1484446 0.84 CYP2A6 (0.38) VCAM1FBP1TTRALBPTGS1
SCHEMBL29472378 0.84 EPAS1 (0.37)
SCHEMBL552453 0.84 ALDH1A1 (0.42) VCAM1EGFRFBP1TTRALB
SCHEMBL77140 0.84 EPAS1 (0.37)
SCHEMBL3637772 0.84 EGFR (0.41) EGFRTTRALBMEN1KMT2A
SCHEMBL31294626 0.84 HSD17B10 (0.38) VCAM1GPR35CA1CA2
SCHEMBL2160541 0.84 HSD17B10 (0.38) VCAM1GPR35CA1CA2
SCHEMBL12465035 0.80 GRM5 (0.35) EGFRFBP1TTRALBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed