SCHEMBL29952397

SCHEMBL29952397

NC(=O)CN(CC(N)=O)c1ccc(C=O)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.57
ALDH3A1 P30838 1/20 0.57
ALDH1A3 P47895 1/20 0.57
CYP2A6 P11509 2/20 0.45
CYP2A13 Q16696 1/20 0.45
MAPT P10636 4/20 0.44
KDM4E B2RXH2 3/20 0.44
GAA P10253 2/20 0.44
GLA P06280 1/20 0.44
HPGD P15428 1/20 0.44
GFER P55789 1/20 0.44
KMT2A Q03164 4/20 0.43
MEN1 O00255 3/20 0.43
POLB P06746 2/20 0.43
PARP10 Q53GL7 1/20 0.41
PARP3 Q9Y6F1 1/20 0.41
ALDH5A1 P51649 1/20 0.40
ABAT P80404 1/20 0.40
MAPK1 P28482 2/20 0.36
TDP1 Q9NUW8 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2560938 0.85 ALDH1A1 (0.50) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL29951287 0.84 ALDH1A1 (0.53) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL342255 0.82 ALDH1A1 (0.59) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL2557220 0.81 CYP2A6 (0.52) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL15330157 0.78 ALDH1A1 (0.44) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL13603931 0.76 NPC1 (0.45) ALDH1A1MAPTKDM4EGAAHPGD
SCHEMBL13603918 0.75 NPSR1 (0.44) ALDH1A1MAPTGLAKMT2AMEN1
SCHEMBL17845859 0.75 ALDH1A1 (0.59) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL29952124 0.75 ALDH1A1 (0.39) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13
SCHEMBL29279286 0.74 ALDH1A1 (0.69) ALDH1A1ALDH3A1ALDH1A3CYP2A6CYP2A13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed