SCHEMBL29952880

SCHEMBL29952880

COc1ccc(C=O)cc1CSc1ncccc1C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.62
ALDH1A1 P00352 8/20 0.56
GAA P10253 1/20 0.56
KDM4E B2RXH2 4/20 0.55
HTT P42858 2/20 0.55
TDP1 Q9NUW8 1/20 0.53
MEN1 O00255 5/20 0.52
KMT2A Q03164 5/20 0.52
HPGD P15428 5/20 0.52
CYP2C9 P11712 2/20 0.51
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.50
TP53 P04637 1/20 0.50
MAPT P10636 2/20 0.49
L3MBTL1 Q9Y468 2/20 0.46
PKM P14618 1/20 0.46
POLB P06746 1/20 0.44
THRB P10828 1/20 0.44
MCL1 Q07820 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1496426 0.76 ALDH1A1 (0.56) ALDH1A1GAAKDM4EHTTTDP1
SCHEMBL9869842 0.71 KMT2A (0.68) ALDH1A1GAAKDM4EHTTTDP1
SCHEMBL4018474 0.71 SMN1; SMN2 (0.65) ALDH1A1GAAKDM4EHTTTDP1
SCHEMBL12870286 0.71 ALDH1A1 (0.79) ALDH1A1GAAKDM4EHTTMEN1
SCHEMBL14227284 0.70 NPSR1 (0.60) NPSR1ALDH1A1HTTMEN1KMT2A
SCHEMBL14399032 0.70 ALDH1A1 (0.81) ALDH1A1GAAKDM4EHTTMEN1
SCHEMBL14399019 0.70 ALDH1A1 (0.81) ALDH1A1GAAKDM4EHTTMEN1
SCHEMBL2934800 0.70 ALDH1A1 (0.61) NPSR1ALDH1A1KDM4ETDP1KMT2A
SCHEMBL29956561 0.70 ALDH1A1 (0.61) NPSR1ALDH1A1KDM4ETDP1KMT2A
SCHEMBL3594763 0.69 ALDH1A1 (1.00) ALDH1A1GAAKDM4EHTTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed