Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956462 | 0.77 | MAPK1 (0.42) | MAPK1ACACBTDP1JAK2CDK8 | |
| SCHEMBL29955581 | 0.74 | JAK2 (0.50) | MAPK1JAK2CDK8IKBKBCHUK | |
| SCHEMBL29952331 | 0.72 | CDK8 (0.47) | MAPK1JAK2CDK8PRKD3MAP4K4 | |
| SCHEMBL29957871 | 0.71 | RPS6KA3 (0.46) | MAPK1JAK2CDK8IKBKBCHUK | |
| SCHEMBL28318061 | 0.68 | JAK2 (0.54) | JAK2CDK8IKBKBCHUKDAPK3 | |
| SCHEMBL14735035 | 0.67 | BRD4 (0.53) | MAPK1TDP1JAK2CDK8IKBKB | |
| SCHEMBL30876997 | 0.67 | MEN1 (0.49) | TDP1ADORA1ADORA3ADORA2AMAPT | |
| SCHEMBL28374065 | 0.67 | MEN1 (0.45) | TDP1ADORA1ADORA3ADORA2AMAPT | |
| SCHEMBL1046938 | 0.66 | MGLL (0.52) | TDP1ADORA1ADORA3ADORA2AMAPT | |
| SCHEMBL16122604 | 0.66 | MEN1 (0.54) | TDP1ADORA1ADORA3ADORA2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |