SCHEMBL29956462

SCHEMBL29956462

O=Cc1cc(-c2ccccc2)nc2[nH]ccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.42
ADORA3 P0DMS8 1/20 0.40
ADORA2A P29274 1/20 0.40
ADORA1 P30542 1/20 0.40
ACACB O00763 1/20 0.40
CDK8 P49336 3/20 0.40
XDH P47989 3/20 0.40
JAK2 O60674 2/20 0.40
MAP2K1 Q02750 2/20 0.40
IKBKB O14920 1/20 0.40
CHUK O15111 1/20 0.40
DAPK3 O43293 1/20 0.40
PRKD3 O94806 1/20 0.40
MAP4K4 O95819 1/20 0.40
PAK4 O96013 1/20 0.40
CSF1R P07333 1/20 0.40
RET P07949 1/20 0.40
IGF1R P08069 1/20 0.40
FGFR1 P11362 1/20 0.40
PRKACA P17612 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29951425 0.77 KMT2A (0.51) ADORA3ADORA2AADORA1CDK9AXL
SCHEMBL14735486 0.77 KMT2A (0.51) ADORA3ADORA2AADORA1CDK9AXL
SCHEMBL29954535 0.77 MAPK1 (0.43) MAPK1ADORA3ADORA2AADORA1ACACB
SCHEMBL2169577 0.76 ACHE (0.56) ALDH1A1KDM4EHPGDHSD17B10MAPT
SCHEMBL26106331 0.74 DYRK1A (0.38) ADORA2AADORA1CDK8CDK9DYRK1A
SCHEMBL30611953 0.74 DYRK1A (0.38) ADORA2AADORA1CDK8CDK9DYRK1A
SCHEMBL29957561 0.74 DYRK1A (0.38) MAPK1ADORA2AADORA1CDK8JAK2
SCHEMBL24528632 0.73 CYP2A6 (0.39) CDK8JAK2MAP2K1IKBKBCHUK
SCHEMBL29680885 0.73 CYP2A6 (0.39) CDK8JAK2MAP2K1IKBKBCHUK
SCHEMBL29953681 0.73 CDK8 (0.50) MAPK1ADORA3ADORA2AADORA1CDK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed