SCHEMBL29954570

SCHEMBL29954570

CC(C)(C)OC(=O)Nc1c(Cl)cc(C=O)cc1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATR Q13535 1/20 0.47
LCK P06239 3/20 0.41
CA12 O43570 2/20 0.37
CA1 P00915 2/20 0.37
CA9 Q16790 2/20 0.37
CA2 P00918 1/20 0.37
MIF P14174 1/20 0.36
HDAC3 O15379 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HTT P42858 1/20 0.36
NPC1 O15118 1/20 0.35
RECQL P46063 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NLRP3 Q96P20 1/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26429672 0.81 ATR (0.41) ATRLCKCA12CA1CA9
SCHEMBL29951650 0.81 ALDH1A1 (0.42) ATRMIFHDAC3HDAC1HDAC2
SCHEMBL19944782 0.81 ALDH1A1 (0.42) ATRMIFHDAC3HDAC1HDAC2
SCHEMBL29953301 0.79 CA12 (0.43) ATRCA12CA1CA9HDAC3
SCHEMBL12527219 0.79 CA12 (0.43) ATRCA12CA1CA9HDAC3
SCHEMBL3119352 0.79 CA12 (0.45) ATRCA12CA1CA9MIF
SCHEMBL29955278 0.78 ATR (0.44) ATRLCKCA12CA1CA9
SCHEMBL29956714 0.78 PDK1 (0.44) ATRMIFHDAC3HDAC1HDAC2
SCHEMBL17208821 0.77 ATR (0.51) ATRLCKNPC1RAB9ACYP17A1
SCHEMBL11611125 0.76 ALDH1A1 (0.41) CA1CA9CA2KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed