SCHEMBL29955728

SCHEMBL29955728

[C-]#[N+]Cc1ccc(C)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.42
ALDH1A1 P00352 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
KDM1A O60341 1/20 0.38
PNMT P11086 1/20 0.36
KDM4E B2RXH2 1/20 0.36
CCR2 P41597 1/20 0.35
MAPT P10636 2/20 0.35
GAA P10253 1/20 0.35
AGTR1 P30556 1/20 0.35
RAPGEF4 Q8WZA2 1/20 0.34
IDO1 P14902 1/20 0.33
DHFR P00374 1/20 0.33
BCDIN3D Q7Z5W3 3/20 0.33
HTR2A P28223 1/20 0.33
SLC6A4 P31645 1/20 0.33
KCNH2 Q12809 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3756416 0.81 IDO1 (0.52) ALDH1A1PNMTMAPTIDO1SLC6A4
SCHEMBL12107538 0.76 CYP3A4 (0.54) CYP3A4ALDH1A1NPSR1KDM1APNMT
SCHEMBL8257731 0.76 DAO (0.41) ALDH1A1DHFRSLC6A4
SCHEMBL925505 0.76 HPGD (0.35) ALDH1A1KDM4EMAPTGAADHFR
SCHEMBL29952853 0.76 PIK3CA (0.41) CYP3A4ALDH1A1NPSR1PNMTKDM4E
SCHEMBL12170298 0.76 KMT2A (0.51) ALDH1A1NPSR1KDM1AMAPTGAA
SCHEMBL30031076 0.74 CYP3A4 (0.48) CYP3A4ALDH1A1NPSR1KDM1APNMT
SCHEMBL4026046 0.74 CYP3A4 (0.48) CYP3A4ALDH1A1NPSR1KDM1APNMT
SCHEMBL1755262 0.74 MAPT (0.49) CYP3A4ALDH1A1NPSR1KDM1AKDM4E
SCHEMBL6126069 0.73 PNMT (0.50) CYP3A4ALDH1A1NPSR1KDM1APNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed